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Voltage-gated calcium and sodium channels are involved in numerous biological processes. Sodium channels support fast propagation of electrical impulses. Calcium channels, in response to the electrical impulses, convey calcium ions into cells, and this can have different effects based on the type of cell. One effect is changes in gene expression in both neuronal and cardiac cells, which is mediated by the influx of calcium and a variety of down-stream partners. The molecular properties of both channels are fine-tuned by a number of proteins, allowing them to perform their wide-ranging biological roles.

Manu Ben–Johny won a 2017 Journal of Biological Chemistry/Herb Tabor Young Investigator Award during the Federation of American Societies for Experimental Biology’s 2017 Conference on Ion Channel Regulation. courtesy of manu ben–johny

, a postdoctoral researcher at Johns Hopkins University, has been researching the molecular and biophysical properties involved in channel fine-tuning, leading to insights into how channel dysfunction may be involved in specific diseases and how synthetic proteins could be used to modulate channel function in a specific manner. For his work, Ben–Johny won a 2017 . “I am truly humbled to receive such an honor from the 91ÑÇÉ«´«Ã½,” Ben–Johny said. “The young investigator awards are an important way to encourage, inspire and promote creativity and scientific rigor in young scientists.”

The award honors contributions to science and recognizes innovative new researchers who exemplify scientific creativity. Ben–Johny was selected by a panel of three experts during the Federation of American Societies for Experimental Biology 2017 on Ion Channel Regulation. “The quality of his poster was outstanding,” said , a member of the panel. “He presented the poster with great enthusiasm, displaying an outstanding depth of knowledge in responding to questions.”

Ben–Johny began his graduate studies at Johns Hopkins with the goal of engineering medical devices. However, his focus changed after meeting his eventual graduate studies mentor, the late . “He spoke elegantly about the voltage-gated calcium ion channel as though it were an electrical device,” Ben–Johny said. “Instead of building devices, I got to apply the same quantitative thinking to unravel deep mysteries about ion channels and their molecular mechanisms.”

Ben–Johny stayed at Johns Hopkins for his postdoctoral studies to continue his research on voltage-gated calcium and sodium channels, including how the calcium-binding protein calmodulin, or CaM, is involved in tuning channel function. He and colleagues have described a mechanism by which CaM signaling to the two ion channels is selectively silenced by different proteins, providing insights into how aberrant signaling may lead to disease.

Ben–Johny’s current research focuses on the interplay of ion channels, CaM/calcium modulation and disease. Calcium channel misregulation has been implicated in human diseases, including cardiac and neurological disorders. “Resolving these pathogenic mechanisms and devising novel strategies to rescue channel function in the context of disease is critical and a worthy endeavor,” Ben–Johny said.

This year Ben–Johny will become an assistant professor at Columbia University, where he plans to continue his research on calcium-regulated ion channels and disease. “As I embark on this new leg of my scientific journey,” he said, “the incredible accomplishments of Herb Tabor both scientifically and in terms of enriching the scientific community serve as an exemplar in my own journey.”