91亚色传媒

Speaker

Associate professor and associate dean of research and advanced graduate studies, University of Maryland School of Pharmacy

Dr. Shapiro received his Bachelor of Science from the University of Wisconsin–Madison in 1987, and his doctorate in molecular physiology and biophysics from the University of Vermont in 1995. He completed post-doctoral training from 1995–1999 in the Department of Chemistry and Biochemistry at the University of Colorado Boulder.

The 91亚色传媒 Breakthroughs webinar series offers a window into the cutting-edge biochemistry and molecular biology research driving discovery.

This month's webinar will discuss mitogen-activated protein kinases (MAPK), their regulation of substrates, and approaches to modulate MAPK functions in disease. MAPK proteins regulate hundreds of substrates, some enhance cell functions whereas others inhibit these functions to balance cellular responses. We'll focus on p38α MAPK or ERK1/2 and regulation of pro- and anti-inflammatory or oncogenic substrates, respectively. Computational and experimental approaches to selectively disrupt pro-inflammatory or oncogenic signals while preserving other kinase functions will be discussed. And we will present an example of a collaboration between academic researchers and industry to translate novel kinase modulators into clinical trials.