O-GlcNAcylation in health and disease
July 10–13, 2025
JB Duke Hotel, Durham, N.C.
2024 marks the 40th anniversary of the discovery of protein O-GlcNAcylation. Since its discovery, the importance of post-translational protein O-GlcNAcylation has been recognized across diverse biomedical research areas. It plays a pivotal role in helping us understand how environmental factors impact signaling pathways and the onset of a range of diseases. This modification of proteins found in the nucleus, mitochondria and cytoplasm has far-reaching implications for governing cellular biology, including epigenetics, cell cycle regulation, proteostasis and more. Additionally, disruptions in O-GlcNAcylation are associated with cardiovascular disease, diabetes, neurological disorders and various forms of cancer.
Despite 40 years of research and over 15,000 substrates described to date, O-GlcNAcylation remains incompletely understood. Recent breakthroughs in identifying the specific functions of proteins and their connections to many diseases have positioned it as an emerging field with important implications for physiology and disease.
This meeting will draw experts from around the world to discuss the O-GlcNAc cycling enzymes and the O-GlcNAc modification in modulating protein function in basic biological processes as well as in disease states, including diabetes, cancer, cardiovascular disease and neurological diseases. Additionally, graduate and postdoctoral students will be selected for oral talks and have opportunities to discuss their work at poster sessions.
If you want to learn about O-GlcNAc, have just started working on this modification, want to find a collaborator for your next project, or learn the latest discovery in the field, this meeting is for you!
Organizers
Duke University
Medical College of Wisconsin
Important dates
| May 12 | Early registration deadline |
|---|---|
| May 12 | Oral abstract deadline |
| May 23 | Poster abstract deadline |
| June 6 | Regular registration deadline |
Sponsors
Speakers
- Emilyn Alejandro, University of Minnesota
- Jerry Hart, University of Georgia
- Billy Wai-Lung Ng, Chinese University of Hong Kong
- Glucin Pekkurnaz, University of California, San Diego
- Tai-ping Sun, Duke University
- Daan Van Aalten, Aarhus University
- Lance Wells, University of Georgia
- Melissa Westwood, University of Manchester
- Xiaoyang Yang, Yale University
Location
The conference will be held at the JB Duke Hotel, 230 Science Drive, Durham, NC 27708.
Health and safety
Mask-wearing and other health and safety measures will be determined based on local, state and venue guidelines and will be communicated to attendees prior to the conference.
Visas
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