91ÑÇÉ«´«Ã½

Organisms can’t avoid stress, so it is not surprising that numerous cellular mechanisms have evolved to temper any toxic effects of stress. Stress responses are triggered within every cellular compartment to activate downstream signaling pathways. Distinct stress responses can lead to production of protective molecular chaperones, alter post-translational modifications and protein trafficking, activate pathways that degrade macromolecules, and change cellular and organellar function and architecture. Together, these responses maintain organelle and cellular homeostasis and, more specifically, protein homeostasis, also known as proteostasis. 

Studies in model systems have uncovered the circuits that control these varied responses, the components that mediate cellular protection, and how disruption or changes in the efficacy of these responses can be linked to specific diseases. Speakers will describe, at the molecular level, how cellular and organelle homeostasis is maintained under normal conditions and when cells and organisms encounter stress. 

Keywords: protein quality control, organelles, stress responses, heat shock proteins, endoplasmic reticulum–associated degradation, autophagy, unfolded protein response 

Who should attend: everyone interested in the diverse mechanisms by which cells cope with stress related to environmental or disease insults, including how different cellular compartments signal stress or respond to restore cellular homeostasis

Theme song: “Under pressure” by David Bowie and Queen

This session is powered by stressed-out cells and organelles.

Learn more

Check out all ten thematic symposia planned for the 2022 91ÑÇÉ«´«Ã½ annual meeting:

• Diversity, equity and inclusion
• Protein machines and disorder
• Signaling
• Quality control in organelles
• Metabolism
• Enzymology
• RNA/DNA
• Membranes/lipids
• Glycobiology
• Education and professional development